4- (Chloromethyl) -7-hydroxycoumarin

4- (Chloromethyl) -7-hydroxycoumarin (compound 4) is a hydroxycoumarin derivative with potent antioxidant effect and high hydroxyl radical-scavenging property. 4- (Chloromethyl) -7-hydroxycoumarin contains a methyl group and a chlorine group in the heterocyclic ring. A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties has been investigated as potent inhibitors of the zinc enzyme carbonic anhydrase, expecially tumor-associated isoforms CA IX and XII[1][2].

Product Specifications

CAS Number

[25392-41-0]

UNSPSC

12352005

Hazard Statement

H302, H314

Target

Drug Derivative

Type

Reference compound

Related Pathways

Others

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/4-chloromethyl-7-hydroxycoumarin.html

Concentration

10mM

Purity

98.01

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C1OC(C=C2O)=C(C=C2)C(CCl)=C1

Molecular Formula

C10H7ClO3

Molecular Weight

210.62

Precautions

H302, H314

References & Citations

[1]Fernanda Pérez-Cruz, et al. Selected hydroxycoumarins as antioxidants in cells: physicochemical and reactive oxygen species scavenging studies. 2013, Oct. 26 (10) :773-783. |[2]Knaus E E , et al. Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II[J]. Bioorganic & Medicinal Chemistry Letters, 2011, 21 (19) :5892-5896.