MTH1 Recombinant Rabbit Monoclonal Antibody [PSH02-40]
Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A . Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA . Through this antimutagenic activity protects cells from oxidative stress .
Product Specifications
CAS Number
9000-83-3
Product Name Alternative
Abbreviation
NUDT1, MTH1
Swiss Prot
P36639 Human, P53368 Mouse, P53369 Rat
Cellular Locus
Cytoplasm, cytosol,Mitochondrion matrix,Nucleus,Mitochondrion matrix
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Recombinant protein within human MTH1 aa 1-156 / 156 (P36639).
Isotype
IgG
Clone
PSH02-40
Conjugation
Non-conjugated
Type
Recombinant Rabbit monoclonal Antibody
Applications
WB, IHC-P, FC
Positive Control
Concentration
1 mg/mL
Dilution
WB: 1:1,000 ;IHC-P: 1:200~1:1,000 ;FC: 1:1,000
Purity
Protein A affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 18 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
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