MTH1 Recombinant Rabbit Monoclonal Antibody [PSH02-40]

Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A . Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA . Through this antimutagenic activity protects cells from oxidative stress .

Product Specifications

CAS Number

9000-83-3

Product Name Alternative

2-hydroxy-dATP diphosphatase antibody 7 8 dihydro 8 oxoguanine triphosphatase antibody 7 antibody 8 oxo 7 8 dihydrodeoxyguanosine triphosphatase antibody 8 oxo 7 8 dihydroguanosine triphosphatase antibody 8 oxo dGTPase antibody 8-dihydro-8-oxoguanine triphosphatase antibody 8-oxo-dGTPase antibody 8ODP_HUMAN antibody MTH 1 antibody MTH1 antibody MutT human homolog 1 antibody Nucleoside diphosphate linked moiety X motif 1 antibody Nucleoside diphosphate linked moiety X type motif 1 antibody Nucleoside diphosphate-linked moiety X motif 1 antibody Nudix (nucleoside diphosphate linked moiety X) type motif 1 antibody Nudix hydrolase 1 antibody Nudix motif 1 antibody Nudix type motif 1 antibody NUDT 1 antibody Nudt1 antibody

Abbreviation

NUDT1, MTH1

Swiss Prot

P36639 Human, P53368 Mouse, P53369 Rat

Cellular Locus

Cytoplasm, cytosol,Mitochondrion matrix,Nucleus,Mitochondrion matrix

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Recombinant protein within human MTH1 aa 1-156 / 156 (P36639).

Isotype

IgG

Clone

PSH02-40

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, FC

Positive Control

HEK-293 cell lysate, HeLa cell lysate, Jurkat cell lysate, HepG2 cell lysate, K-562 cell lysate, A549 cell lysate, MCF7 cell lysate, SW480 cell lysate, THP-1 cell lysate, SK-OV-3 cell lysate, U-2 OS cell lysate, human breast cancer tissue, NIH/3T3 cell lysate, C2C12 cell lysate, bEnd.3 cell lysate, RAW264.7 cell lysate, F9 cell lysate, Neuro-2a cell lysate, C6 cell lysate, L6 cell lysate, PC-12 cell lysate, mouse thymus tissue lysate, rat thymus tissue lysate, mouse testis tissue lysate, rat testis tissue lysate, human stomach cancer tissue, human thymus tissue, rat thymus tissue, Jurkat.