JAK-IN-25
Product Specifications
UNSPSC Description
JAK-IN-25 (compound 19) is a potent JAK inhibitor with IC50s of 6 nM, 21 nM, 8 nM, 1051 nM for TYK2, JAK1, JAK2, JAK3, respectively. JAK-IN-25 inhibits human whole blood IL-12 (HEB IL-12) with an IC50 of 28 nM. JAK-IN-25 has the potential for cancer research[1].
Target Antigen
JAK
Type
Reference compound
Related Pathways
Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jak-in-25.html
Solubility
DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(C1=NN2C=C(C3=CN(CC4=CC=C(C=C4)OC)N=C3)NC(C2=C1)=O)OC
Molecular Weight
379.37
References & Citations
[1]Matthew Frank Brown, et al. Pyrazolo[1,5-a]pyrazin-4-yl derivatives. US20230045252A1.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-153440/JAK-IN-25-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-153440/JAK-IN-25-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2127110-22-7
Available Sizes
Curated Selection
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