3-Chloro-5-hydroxybenzoic acid

3-Chloro-5-hydroxybenzoic acid is a potent, orally active and selective lactate receptor GPR81 agonist, with an EC50 of 16 μM for human GPR81. 3-Chloro-5-hydroxybenzoic acid exhibits favorable in vivo effects on lipolysis in a mouse model of obesity[1].

Product Specifications

CAS Number

[53984-36-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H318, H335

Target

Hydroxycarboxylic Acid Receptor (HCAR)

Type

Reference compound

Related Pathways

GPCR/G Protein

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/3-chloro-5-hydroxybenzoic-acid.html

Concentration

10mM

Purity

99.54

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC1=CC(O)=CC(C(O)=O)=C1

Molecular Formula

C7H5ClO3

Molecular Weight

172.57

Precautions

H302, H315, H318, H335

References & Citations

[1]Dvorak CA, et al. Identification of Hydroxybenzoic Acids as Selective Lactate Receptor (GPR81) Agonists with Antilipolytic Effects. ACS Med Chem Lett. 2012;3 (8) :637-639. Published 2012 Jun 11.