D 15413

D 15413 is an orally active antagonist for nonsteroidal estrogen. D 15413 inhibits growth of estrogen receptor positive MCF-7 cell with an inhibition rate of 70% at 10-7 M. D 15413 exhibits antitumor efficacy against DMBA (HY-W011845) or MNU (HY-34758) -induced breast cancer[1].

Product Specifications

CAS Number

[83364-03-8]

UNSPSC

12352005

Target

Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/d-15413.html

Smiles

ClC1=C(C=C(N2CC)C3=C(C=C(C=C3Cl)O)Cl)C2=CC(O)=C1

Molecular Formula

C16H12Cl3NO2

Molecular Weight

356.63

References & Citations

[1]von Angerer E, et al., The inhibitory effect of 4-chloro-2- (2,6-dichloro-4-hydroxyphenyl) -1-ethyl-6-hydroxyindole (D 15413) on estrogen-dependent mammary tumors. J Cancer Res Clin Oncol. 1985;110 (3) :216-20.