D 15413
D 15413 is an orally active antagonist for nonsteroidal estrogen. D 15413 inhibits growth of estrogen receptor positive MCF-7 cell with an inhibition rate of 70% at 10-7 M. D 15413 exhibits antitumor efficacy against DMBA or MNU (HY-34758) -induced breast cancer[1].
Product Specifications
CAS Number
83364-03-8
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/d-15413.html
Smiles
ClC1=C(C=C(N2CC)C3=C(C=C(C=C3Cl)O)Cl)C2=CC(O)=C1
Molecular Formula
C16H12Cl3NO2
Molecular Weight
356.63
References & Citations
[1]von Angerer E, et al., The inhibitory effect of 4-chloro-2- (2,6-dichloro-4-hydroxyphenyl) -1-ethyl-6-hydroxyindole (D 15413) on estrogen-dependent mammary tumors. J Cancer Res Clin Oncol. 1985;110 (3) :216-20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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