Tideglusib

Tideglusib (NP031112) is an irreversible GSK-3 inhibitor with IC50s of 5 nM and 60 nM for GSK-3βWT (1 h preincubation) and GSK-3βC199A (1 h preincubation), respectively.

Product Specifications

CAS Number

[865854-05-3]

Product Name Alternative

NP031112

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GSK-3

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Tideglusib.html

Concentration

10mM

Purity

99.76

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C(N(SC1=O)C2=C3C=CC=CC3=CC=C2)N1CC4=CC=CC=C4

Molecular Formula

C19H14N2O2S

Molecular Weight

334.39

Precautions

H302, H315, H319, H335

References & Citations

[1]Domínguez JM, et al. Evidence for irreversible inhibition of glycogen synthase kinase-3β by tideglusib. J Biol Chem, 2012, 287 (2), 893-90|[2]Luna-Medina R, et al. NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders. J Neurosci, 2007, 27 (21), 5766-5776.