6-Aminochrysene

6-Aminochrysene (6-Aminochrysene) is an aromatic amine used as a chemotherapeutic agent in the treatment of splenomegaly, myeloid leukemia, and breast cancer. 6-Aminochrysene is activated by CYP450 in rat liver[1][2][3].

Product Specifications

CAS Number

[2642-98-0]

Product Name Alternative

6-Chrysenamine

UNSPSC

12352005

Hazard Statement

H302

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/6-Aminochrysene.html

Purity

99.71

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

NC1=C2C=CC=CC2=C3C(C4=CC=CC=C4C=C3)=C1

Molecular Formula

C18H13N

Molecular Weight

243.30

Precautions

H302

References & Citations

[1]Russo R, et al. Effects of 6-aminochrysene on liver microsomal enzyme activity. Xenobiotica. 1976 Apr;6 (4) :201-5.|[2]Lambelin G, et al. Carcinogenicity of 6-aminochrysene in mice. Eur J Cancer. 1975 May;11 (5) :327-34.|[3]Yamazaki H, et al. Roles of different forms of cytochrome P450 in the activation of the promutagen 6-aminochrysene to genotoxic metabolites in human liver microsomes. Carcinogenesis. 1993 Jul;14 (7) :1271-8.