Human Factor VIIa GLA Domainless

<strong>Human Factor VIIa GLA Domainless</strong>_x000D_ <strong>Catalog number:</strong> B2013765_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 0.10 mg_x000D_ <strong>Molecular Weight or Concentration:</strong> 0.76 mg/mL_x000D_ <strong>Supplied as:</strong> N/A_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20°C_x000D_ <strong>Keywords:</strong> Human Factor VIIa gla domainless_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Murakami MT, Rios-Steiner J, Weaver SE, Tulinsky A, Geiger JH, Arni RK. Intermolecular interactions and characterization of the novel factor Xa exosite involved in macromolecular recognition and inhibition: crystal structure of human Gla-domainless factor Xa complexed with the anticoagulant protein NAPc2 from the hematophagous nematode Ancylostoma caninum J Mol Biol. 2007 Feb 16;366(2):602-10._x000D_ 2: Coppola R, Tombesi S, Valentini F, Alborali S, Albertini A, Mannucci PM. Characterization of a Ca (II)-independent monoclonal antibody that lacks reactivity with Gla-domainless human factor VII Thromb Res. 1992 Nov 1;68(3):269-81._x000D_ 3: Hamamoto T, Foster DC, Kisiel W. The inhibition of human factor VIIa-tissue factor by antithrombin III-heparin is enhanced by factor X on a human bladder carcinoma cell line Int J Hematol. 1996 Jan;63(1):51-63._x000D_ 4: Neuenschwander PF, Morrissey JH. Roles of the membrane-interactive regions of factor VIIa and tissue factor. The factor VIIa Gla domain is dispensable for binding to tissue factor but important for activation of factor X J Biol Chem. 1994 Mar 18;269(11):8007-13._x000D_ 5: Thomsen MK, Wildgoose P, Nilsson P, Hedner U. Accumulation of the recombinant factor VIIa in rat bone: importance of the Gla-domain and relevance to factor IX, another vitamin K-dependent clotting factor Pharmacol Toxicol. 1993 Sep;73(3):127-32._x000D_ 6: McCallum CD, Su B, Neuenschwander PF, Morrissey JH, Johnson AE. Tissue factor positions and maintains the factor VIIa active site far above the membrane surface even in the absence of the factor VIIa Gla domain. A fluorescence resonance energy transfer study J Biol Chem. 1997 Nov 28;272(48):30160-6._x000D_ 7: Osterlund M, Owenius R, Persson E, Lindgren M, Carlsson U, Freskgrd PO, Svensson M. Spectroscopic probing of the influence of calcium and the gla domain on the interaction between the first EGF domain in factor VIIa and tissue factor Eur J Biochem. 2000 Oct;267(20):6204-11._x000D_ 8: Huang Q, Neuenschwander PF, Rezaie AR, Morrissey JH. Substrate recognition by tissue factor-factor VIIa. Evidence for interaction of residues Lys165 and Lys166 of tissue factor with the 4-carboxyglutamate-rich domain of factor X J Biol Chem. 1996 Sep 6;271(36):21752-7._x000D_ 9: Perera L, Foley C, Darden TA, Stafford D, Mather T, Esmon CT, Pedersen LG. Modeling zymogen protein C Biophys J. 2000 Dec;79(6):2925-43._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/16757484">10: Bajaj SP, Schmidt AE, Agah S, Bajaj MS, Padmanabhan K. High resolution structures of p-aminobenzamidine- and benzamidine-VIIa/soluble tissue factor: unpredicted conformation of the 192-193 peptide bond and mapping of Ca2+, Mg2+, Na+, and Zn2+ sites in factor VIIa J Biol Chem. 2006 Aug 25;281(34):24873-88. </a>_x000D_ _x000D_ <strong>Products Related to Human Factor VIIa GLA Domainless can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>