Micheliolide

Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056) -induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282) -induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis[1][2][3][4].

Product Specifications

CAS Number

[68370-47-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Akt; NF-κB; PI3K; TGF-beta/Smad

Type

Natural Products

Related Pathways

NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/micheliolide.html

Purity

99.77

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O[C@@]1([H])[C@@]2([H])CCC(C)=C3CC[C@@](C)(O)[C@@]31[H])C2=C

Molecular Formula

C15H20O3

Molecular Weight

248.32

Precautions

H302, H315, H319, H335

References & Citations

[1]Jia QQ, et al. Sesquiterpene lactones and their derivatives inhibit high glucose-induced NF-κB activation and MCP-1 and TGF-β1 expression in rat mesangial cells. Molecules. 2013 Oct 21;18 (10) :13061-77.|[2]Qin X, et al. Micheliolide inhibits LPS-induced inflammatory response and protects mice from LPS challenge. Sci Rep. 2016 Mar 17;6:23240. |[3]Viennois E, et al. Micheliolide, a new sesquiterpene lactone that inhibits intestinal inflammation and colitis-associated cancer. Lab Invest. 2014 Sep;94 (9) :950-65. |[4]Xu H, et al. Therapeutic effects of micheliolide on a murine model of rheumatoid arthritis. Mol Med Rep. 2015 Jan;11 (1) :489-93.