Micheliolide
Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS -induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282) -induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis[1][2][3][4].
Product Specifications
CAS Number
68370-47-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Akt; NF-κB; PI3K; TGF-beta/Smad
Type
Natural Products
Related Pathways
NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/micheliolide.html
Purity
99.77
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O[C@@]1([H])[C@@]2([H])CCC(C)=C3CC[C@@](C)(O)[C@@]31[H])C2=C
Molecular Formula
C15H20O3
Molecular Weight
248.32
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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