Bragsin2
Bragsin2 is a potent, selective and noncompetitive nucleotide exchange factor BRAG2 inhibitor, with an IC50 of 3 μM. Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer, leads BRAG2 unable to activate lipidated Arf GTPase. Bragsin2 affects breast cancer stem cells[1].
Product Specifications
CAS Number
342795-08-8
UNSPSC
12352005
Target
MDM-2/p53; Ras
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Bragsin2.html
Purity
99.85
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C=C(C(F)(F)F)OC2=CC=C(OC)C([N+]([O-])=O)=C21
Molecular Formula
C11H6F3NO5
Molecular Weight
289.16
References & Citations
[1]Nawrotek A, et al. PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling. Nat Chem Biol. 2019 Feb 11. doi: 10.1038/s41589-019-0228-3.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC680853-100 1x 100 µL
P34 / cdk1 (POH-1), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details ![HSP27 (HSPB1) Mouse Monoclonal Antibody [Clone ID: 2A5]](https://cdn.genprice.uk/products/937/68dd189b061270361e8fc375/imageurl/am09016pu-n.webp)
AM09016PU-N 100 µL
HSP27 (HSPB1) Mouse Monoclonal Antibody [Clone ID: 2A5]
Sign In for Pricing
View Details 
TRC-D453530-2.5MG 2.5 mg
17,20Beta-Dihydroxypregn-4-en-3-one 20-Acetate
Sign In for Pricing
View Details ![MGST1 Mouse Monoclonal Antibody [14H2]](https://cdn.genprice.uk/products/992/68dd1c8c061270361ea81a01/imageurl/em1901-13.webp)
![Von Willebrand Factor (VWF) Mouse Monoclonal Antibody [Clone ID: SPM577]](https://cdn.genprice.uk/products/937/68dd189e061270361e8fd7d6/imageurl/am50187pu-t.webp)
AM50187PU-T 20 µg
Von Willebrand Factor (VWF) Mouse Monoclonal Antibody [Clone ID: SPM577]
Sign In for Pricing
View Details 