1-Monopalmitin

1-Monopalmitin (Glyceryl palmitate) is an activator of the PI3K/Akt pathway and an inhibitor of P-glycoprotein (P-gp) . 1-Monopalmitin can induce G2/M arrest and caspase-dependent apoptosis in cancer cells, while inhibiting IAPs protein expression. 1-Monopalmitin can increase drug accumulation by inhibiting P-gp activity in intestinal Caco-2 cells. 1-Monopalmitin has the ability to induce protective autophagy and apoptosis of lung cancer cells (IC50=50-58 μg/mL), with low toxicity to normal cells[1][2].

Product Specifications

CAS Number

[542-44-9]

Product Name Alternative

Glyceryl palmitate

UNSPSC

12352211

Hazard Statement

H302

Target

Akt; Apoptosis; Caspase; IAP; P-glycoprotein; PI3K

Type

Natural Products

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel; PI3K/Akt/mTOR

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/1-monopalmitin.html

Concentration

10mM

Purity

99.89

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 50 mg/mL (warming; heat to 60°C)

Smiles

OC(CO)COC(CCCCCCCCCCCCCCC)=O

Molecular Formula

C19H38O4

Molecular Weight

330.51

Precautions

H302

References & Citations

[1]Niu L, et al. 1-Monopalmitin promotes lung cancer cells apoptosis through PI3K/A kt pathway in vitro. Environmental Toxicology, 2023, 38 (11) : 2621-2631.|[2]Tomoko Konishi, et al. A bitter melon extract inhibits the P-glycoprotein activity in intestinal Caco-2 cells: monoglyceride as an active compound. Biofactors. 2004;22 (1-4) :71-4.