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NU2058

NU2058 (O6- (Cyclohexylmethyl) guanine) is a potent, competitive and guanine-based CDK inhibitor with IC50s of 17 μM and 26 μM for CDK2 and CDK1. NU2058 has anti-cancer activity.

Product Specifications

CAS Number

161058-83-9

Product Name Alternative

O6- (Cyclohexylmethyl) guanine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/NU2058.html

Purity

99.66

Solubility

DMSO : ≥ 32 mg/mL

Smiles

NC1=NC(OCC2CCCCC2)=C3NC=NC3=N1

Molecular Formula

C12H17N5O

Molecular Weight

247.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Rigas AC, et al. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer. Oncogene. 2007 Dec 6;26 (55) :7611-7619.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK1; CDK2

Available Sizes

Frequently Asked Questions

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