NU2058
NU2058 (O6- (Cyclohexylmethyl) guanine) is a potent, competitive and guanine-based CDK inhibitor with IC50s of 17 μM and 26 μM for CDK2 and CDK1. NU2058 has anti-cancer activity.
Product Specifications
CAS Number
[161058-83-9]
Product Name Alternative
O6- (Cyclohexylmethyl) guanine
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NU2058.html
Purity
99.66
Solubility
DMSO : ≥ 32 mg/mL
Smiles
NC1=NC(OCC2CCCCC2)=C3NC=NC3=N1
Molecular Formula
C12H17N5O
Molecular Weight
247.30
Precautions
H302, H315, H319, H335
References & Citations
[1]Rigas AC, et al. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer. Oncogene. 2007 Dec 6;26 (55) :7611-7619.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK2
Available Sizes
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