FLS-359
FLS-359 is a selective, orally active allosteric modulator for sirtuin 2, with the IC50 of 3 μM. FLS-359 exhibits antiviral activity against RNA and DNA virus, through inhibition of DNA/RNA replication[1].
Product Specifications
CAS Number
2309398-79-4
UNSPSC
12352005
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/fls-359.html
Solubility
10 mM in DMSO
Smiles
CC1=CN(C(C)=N1)C2=CC=C3CCN(CC3=C2)C4=NC=C(S4)CC5=CC=C(C=C5)N6C=CC=N6
Molecular Formula
C27H26N6S
Molecular Weight
466.60
References & Citations
[1]Roche KL, et al., An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity. J Clin Invest. 2023 Jun 15;133 (12) :e158978.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT2
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