Ulefnersen (sodium)

Ulefnersen sodium (ION363) is an Antisense Oligonucleotide (ASO) directed against the 6th intron of the fused-in sarcoma (FUS) transcript to silence FUS in a non-allele-specific manner. Ulefnersen sodium can reduce postnatal levels of FUS protein in the brain and spinal cord in disease-relevant mouse model of ALS-FUS , delaying motor neuron degeneration. Ulefnersen sodium can be used in the research of Amyotrophic Lateral Sclerosis (ALS) [1].

Product Specifications

CAS Number

[2589926-27-0]

Product Name Alternative

ION-363 (sodium)

UNSPSC

12352208

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ulefnersen-sodium.html

Purity

98.47

Solubility

H2O : ≥ 25 mg/mL

Smiles

[Ulefnersen(sodium)]

Molecular Formula

C230H302N68O126P19S13Na19

Molecular Weight

7060 (free acid)

Precautions

H302, H315, H319, H335

References & Citations

[1]Korobeynikov VA, Lyashchenko AK, Blanco-Redondo B, Jafar-Nejad P, Shneider NA. Antisense oligonucleotide silencing of FUS expression as a therapeutic approach in amyotrophic lateral sclerosis. Nat Med. 2022;28 (1) :104-116.