Recombinant Human PD-L1 Protein (Sumo Tag)

Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1 (PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.

PDL; B7H; PD-L; PD1L; Programmed cell death 1 ligand; PDCD1L; PDCD1LG; B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1; CD274; B7-H1; B7 homolog 1; CD274 molecule; PDCD1 ligand 1; Programmed death ligand 1; PD1L1; Programmed cell death 1 ligand 1; PDL1; PD-L1; B7-H; B7H1; CD274 molecule; PDCD1L1; PDCD1LG1; B7 H; B7 H1; CD 274; CD274 antigen; MGC142294; MGC142296; OTTHUMP00000021029; PD L1; PDL 1; RGD1566211

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.