10-Nitrooleic acid

10-Nitrooleic acid (CXA-10), a nitro fatty acid, has potential effects in disease states in which oxidative stress, inflammation, fibrosis, and/or direct tissue toxicity play significant roles[1].

Product Specifications

CAS Number

[875685-46-4]

Product Name Alternative

CXA-10; 10-Nitrooleate

UNSPSC

12352211

Hazard Statement

H225, H319

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/10-nitrooleic-acid.html

Concentration

1.53 mM * 200 μL in Ethanol

Purity

98.89

Solubility

10 mM in DMSO

Smiles

CCCCCCCC/C([N+]([O-])=O)=C\CCCCCCCC(O)=O

Molecular Formula

C18H33NO4

Molecular Weight

327.46

Precautions

H225, H319

References & Citations

[1]Garner RM, Mould DR, Chieffo C, Jorkasky DK. Pharmacokinetic and Pharmacodynamic Effects of Oral CXA-10, a Nitro Fatty Acid, After Single and Multiple Ascending Doses in Healthy and Obese Subjects. Clin Transl Sci. 2019;12 (6) :667-676. |[2]Zheng R, et al. Regulation of keratinocyte expression of stress proteins and antioxidants by the electrophilic nitrofatty acids 9- and 10-nitrooleic acid. Free Radic Biol Med. 2014;67:1-9.