Cotinine
Cotinine ((-) -Cotinine) is an orally active alkaloid found in tobacco and is the primary metabolite of nicotine. Cotinine is metabolized by CYP2A13 into trans-3'-hydroxycotinine. Cotinine is used as a biomarker to measure exposure to tobacco smoke components. Cotinine has vasodepressor activity. The mixture of cotinine and nicotine (Nicotine) has antiproliferative activity against pterygium. (S) - (-) -Cotinine activates nicotinic acetylcholine receptors (nAChR) in a calcium-dependent manner, leading to the release of dopamine (Dopamine, HY-B0451). Cotinine ((-) -Cotinine) is used in research related to cardiovascular and inflammatory diseases[1][2][3][4][5].
Product Specifications
CAS Number
486-56-6
Product Name Alternative
(-) -Cotinine; (S) -Cotinine; NIH-10498
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; nAChR
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Cotinine.html
Purity
99.98
Solubility
DMSO : 65 mg/mL (ultrasonic) |Ethanol : 120 mg/mL (ultrasonic)
Smiles
O=C1N(C)[C@H](C2=CC=CN=C2)CC1
Molecular Formula
C10H12N2O
Molecular Weight
176.22
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
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