OES2-0017

OES2-0017 shows potent synergy with polyamines and growth-inhibitory effects at the low micromolar range. OES2-0017 inhibits spermine/spermidine acetyltransferase (SpeG) (IC50: 34.82 μM) and other polyamine detoxification enzymes in low concentrations, perturbed the bacterial membrane in higher concentrations[1].

Product Specifications

CAS Number

[5538-95-4]

UNSPSC

12352211

Hazard Statement

H302-H314-H400

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/oes2-0017.html

Purity

99.48

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCCCCCCCCCCNCCCN

Molecular Formula

C15H34N2

Molecular Weight

242.44

Precautions

P260-P264-P270-P273-P280-P301+P330+P331-P304+P340-P330-P363-P391-P405-P501

References & Citations

[1]Peri B Moulding, et al. Discovery of broad-spectrum bacterial polyamine detoxification inhibitors as potential antivirulence agents and antibiotic adjuvants. bioRxiv, 2024-10.