SR 57227A

SR 57227A is a potent, orally active and selective 5-HT3 receptor agonist, with ability to cross the blood brain barrier. SR 57227A has affinities (IC50) varying between 2.8 and 250 nM for 5-HT3 receptor binding sites in rat cortical membranes and on whole NG 108-15 cells or their membranes. Anti-depressant effects[1][2].

Product Specifications

CAS Number

[77145-61-0]

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sr-57227a.html

Purity

99.76

Solubility

DMSO : 8.33 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic)

Smiles

ClC1=NC(N2CCC(N)CC2)=CC=C1.[H]Cl

Molecular Formula

C10H15Cl2N3

Molecular Weight

248.15

Precautions

H301, H315, H319, H335

References & Citations

[1]Poncelet M, et al, Le Fur G. Antidepressant-like effects of SR 57227A, a 5-HT3 receptor agonist, in rodents. J Neural Transm Gen Sect. 1995;102 (2) :83‐90.|[2]Bachy A, et al. SR 57227A: a potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo. Eur J Pharmacol. 1993;237 (2-3) :299‐309.