Iba1 Recombinant Antibody [JM36-62] - Rat IgG1 (Chimeric)
Ionized calcium-binding adapter molecule 1 (Iba1), also known as allograft inflammatory factor-1 (AIF-1), is a 147 amino acid cytoplasmic, calcium-binding protein that is thought to play a role in macrophage activation and function. Iba1, containing two EF domains, is induced by cytokines and interferons. In an unstimulated state, Iba1 colocalizes with actin, and upon stimulation, translocates to lamellipodia. It is also a marker of human microglia and is expressed by macrophages in injured skeletal muscle. The gene encoding Iba1 maps to chromosome 6p21.33 and resides in the tumor necrosis factor (TNF) cluster of genes located in the region represented by the human major histocompatibility complex (MHC).
Product Specifications
Product Name Alternative
Abbreviation
AIF-1, AIF1, G1, IBA1
Swiss Prot
P55008 Human, O70200 Mouse, P55009 Rat
Cellular Locus
Cytoplasm, cytoskeleton, Cell projection, ruffle membrane, Cell projection, phagocytic cup.
Species Reactivity
Mouse,Rat
Immunogen
Synthetic peptide within N-terminal human Iba1.
Clone
JM36-62
Conjugation
Non-conjugated
Type
Recombinant Chimeric Antibody Antibody
Applications
IHC-Fr, IHC-P
Positive Control
Mouse brain tissue, mouse striatum tissue, rat striatum tissue.
Concentration
1 mg/mL
Dilution
IHC-Fr: 1:1,000 ;IHC-P: 1:100-1:500
Purity
Protein A affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 17 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
Yes
CAS Number
9000-83-3
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