Mdivi-1

Mdivi-1 is a selective dynamin-related protein 1 (Drp1) inhibitor. Mdivi-1 is a mitochondrial division/mitophagy inhibitor.

Product Specifications

CAS Number

[338967-87-6]

Product Name Alternative

Mitochondrial division inhibitor 1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; Dynamin; Mitophagy

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Mdivi-1.html

Purity

99.96

Solubility

DMSO : 110 mg/mL (ultrasonic)

Smiles

O=C1N(C2=C(Cl)C=C(Cl)C(OC)=C2)C(S)=NC3=C1C=CC=C3

Molecular Formula

C15H10Cl2N2O2S

Molecular Weight

353.22

Precautions

H302, H315, H319, H335

References & Citations

[1]Cassidy-Stone A, et al. Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. Dev Cell. 2008 Feb;14 (2) :193-204.|[2]Tanaka A, et al. A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis. Mol Cell. 2008 Feb 29;29 (4) :409-10.|[3]Park SW, et al. A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina. Invest Ophthalmol Vis Sci. 2011 Apr 27;52 (5) :2837-43.