(S) -Timolol (maleate)

(S) -Timolol Maleate (L-714,465 Maleate) is a non-cardioselective hydrophilic β-adrenoceptor blocker. (S) -Timolol Maleate is widely used as standard medication for intraocular pressure (glaucoma) by preventing the production of aqueous humor. (S) -Timolol Maleate can be used for hypertension, angina pectoris and myocardial infarction[1][2][3].

Product Specifications

CAS Number

[26921-17-5]

Product Name Alternative

(S) -L-714,465 (maleate) ; MK 950

UNSPSC

12352005

Hazard Statement

H302, H361

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/s-timolol-maleate.html

Concentration

10mM

Purity

99.89

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 50 mg/mL (ultrasonic)

Smiles

O[C@H](COC1=NSN=C1N2CCOCC2)CNC(C)(C)C.O=C(O)/C=C\C(O)=O

Molecular Formula

C17H28N4O7S

Molecular Weight

432.49

Precautions

H302, H361

References & Citations

[1]Mitrović M, et al. Analytical quality by design development of an ecologically acceptable enantioselective HPLC method for timolol maleate enantiomeric purity testing on ovomucoid chiral stationary phase. J Pharm Biomed Anal. 2020 Feb 20;180:113034.|[2]Wedian F, et al. Simultaneous spectrofluorometric analysis of tablets containing hydrochlorothiazide combined with timolol maleate or amiloride hydrochloride. Acta Pharm. 2020 Sep 1;70 (3) :373-385.|[3]Sun L, et al. Fractional 2940-nm Er:YAG Laser-Assisted Drug Delivery of Timolol Maleate for the Treatment of Deep Infantile Hemangioma. J Dermatolog Treat. 2020 Feb 11:1-24.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

β adrenergic receptor

Citation 01

Adv Mater. 2025 Jan 6:e2419306.|Mater Today Bio. 2025 Apr 12:32:101752.|Protein Cell. 2019 Mar;10 (3) :178-195.|Patent. US20230090708A1.|Redox Biol. 2024 Dec 21:79:103481.