CL-184005
Product Specifications
UNSPSC Description
CL-184005 is an antagonist for platelet-activating factor (PAF), that inhibits the PAF-induced platelet aggregation with IC50 of 600 nM and 510 nM, in human and rabbit platelet-rich plasma. CL-184005 protects the rats from endotoxin-induced gastrointestinal damage and hypotension. CL-184005 exhibits potential attenuating Gram-negative bacterial sepsis[1].
Target Antigen
Platelet-activating Factor Receptor (PAFR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cl-184005.html
Smiles
CC1=C[N+](CC2=CC=CC(OP(OC3=CC=CC(OCCCCCCCCCCCCCC)=C3C(OC)=O)([O-])=O)=C2)=CS1
Molecular Weight
631.76
References & Citations
[1]Torley LW, et al., Studies of the effect of a platelet-activating factor antagonist, CL 184,005, in animal models of gram-negative bacterial sepsis. Antimicrob Agents Chemother. 1992 Sep;36(9):1971-7.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-19126/CL-184005-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-19126/
Clinical Information
No Development Reported
CAS Number
140466-18-8
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