CL-184005
CL-184005 is an antagonist for platelet-activating factor (PAF), that inhibits the PAF-induced platelet aggregation with IC50 of 600 nM and 510 nM, in human and rabbit platelet-rich plasma. CL-184005 protects the rats from endotoxin-induced gastrointestinal damage and hypotension. CL-184005 exhibits potential attenuating Gram-negative bacterial sepsis[1].
Product Specifications
CAS Number
[140466-18-8]
UNSPSC
12352005
Target
Platelet-activating Factor Receptor (PAFR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cl-184005.html
Smiles
CC1=C[N+](CC2=CC=CC(OP(OC3=CC=CC(OCCCCCCCCCCCCCC)=C3C(OC)=O)([O-])=O)=C2)=CS1
Molecular Formula
C33H46NO7PS
Molecular Weight
631.76
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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