5-Octyl-α-ketoglutarate
5-Octyl-α-ketoglutarate (5-Octyl 2-oxopentanedioate) is a cell-permeable substrate for lysine demethylase. 5-Octyl-α-ketoglutarate is related to protein demethylation, inhibits cell proliferation of wtCRBN expressing cells, and also enhances Lenalidomide -induced sensitivity and inhibits myeloma (MM) ) drug resistance of cells. When myeloma (MM) cells undergo glutamine-dependent proliferation, α-ketoglutarate increases glutamine catabolism to promote protein demethylation[1].
Product Specifications
CAS Number
1616344-00-3
Product Name Alternative
5-Octyl 2-oxopentanedioate
UNSPSC
12352211
Target
E1/E2/E3 Enzyme; Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/5-octyl-α-ketoglutarate.html
Solubility
10 mM in DMSO
Smiles
O=C(C(CCC(OCCCCCCCC)=O)=O)O
Molecular Formula
C13H22O5
Molecular Weight
258.31
References & Citations
[1]Chirackal S, et al. Myeloma Cells Addicted to Glutamine for Biomass Production Are Sensitive to Lenalidomide[J]. Blood, 2019, 134: 4410.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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