VU0469650
VU0469650 is a potent, selective and CNS-penetrated negative allosteric modulator of mGlu1 receptor, with an IC50 of 99 nM[1].
Product Specifications
CAS Number
[1443748-47-7]
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu0469650.html
Purity
98.70
Solubility
DMSO : 41.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N1[C@@H](CN(C2=C(N=CC=C2)C#N)CC1)C)C34C[C@H](C5)C[C@H](C[C@H]5C4)C3
Molecular Formula
C22H28N4O
Molecular Weight
364.48
References & Citations
[1]Lovell KM, Felts AS, Rodriguez AL, et al. N-Acyl-N'-arylpiperazines as negative allosteric modulators of mGlu1: identification of VU0469650, a potent and selective tool compound with CNS exposure in rats. Bioorg Med Chem Lett. 2013;23 (13) :3713-3718.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR1
Available Sizes
Curated Selection
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