Enniatin A

Enniatin A is a Fusarium mycotoxin. Enniatin A inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 22 μM in an enzyme assay using rat liver microsomes[1].

Product Specifications

CAS Number

[2503-13-1]

UNSPSC

12352005

Hazard Statement

H301+H311+H331

Target

Acyltransferase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/enniatin-a.html

Solubility

10 mM in DMSO

Smiles

CC[C@@H]([C@]1([H])N(C([C@H](OC(C(N(C([C@@H](C(C)C)OC([C@@]([C@@H](C)CC)([H])N(C)C([C@](C(C)C)([H])OC1=O)=O)=O)=O)C)[C@@H](C)CC)=O)C(C)C)=O)C)C

Molecular Formula

C36H63N3O9

Molecular Weight

681.90

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501

References & Citations

[1]Tomoda H, et al. Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics. J Antibiot (Tokyo) . 1992 Oct;45 (10) :1626-32.|[2]Mamur S, et al. Assessment of cytotoxic and genotoxic effects of enniatin-A in vitro. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2018 Aug;35 (8) :1633-1644.