Factor D inhibitor 6
Factor D inhibitor 6 is a potent, highly selective and orally active factor D (FD) inhibitor with an IC50 of 30 nM and a Kd of 6 nM. Factor D inhibitor 6 is inactive against factor B, lassical and lectin complement-pathway activation, and a broad assay panel of receptors, ion channels, kinases and proteases[1].
Product Specifications
CAS Number
[1386455-51-1]
UNSPSC
12352005
Target
Complement System
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/factor-d-inhibitor-6.html
Purity
99.18
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C([C@H]1N(C(CN2N=C(C(N)=O)C3=C2C=NC=C3)=O)[C@]4([H])C[C@]4([H])C1)N[C@@H](C5=CC=CC(Cl)=C5F)C
Molecular Formula
C23H22ClFN6O3
Molecular Weight
484.91
References & Citations
[1]Jürgen Maibaum, et al. Small-molecule Factor D Inhibitors Targeting the Alternative Complement Pathway. Nat Chem Biol. 2016 Dec;12 (12) :1105-1110.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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