FAAH-IN-2

FAAH-IN-2 (O-Desmorpholinopropyl Gefitinib) is an inhibitor of FAAH. FAAH-IN-2 is a metabolite of Gefitinib (HY-50895) [1][2][3].

Product Specifications

CAS Number

[184475-71-6]

Product Name Alternative

O-Desmorpholinopropyl Gefitinib

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; FAAH

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/FAAH-IN-2.html

Purity

99.29

Solubility

DMSO : 20.83 mg/mL (ultrasonic)

Smiles

OC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OC

Molecular Formula

C15H11ClFN3O2

Molecular Weight

319.72

Precautions

H302, H315, H319, H335

References & Citations

[1]Olivier Dasse, et al. Carbamates therapeutic release agents as amidase inhibitors. WO/2008/100977A2.|[2]Zhu Y, et al. FAAH served a key membrane-anchoring and stabilizing role for NLRP3 protein independently of the endocannabinoid system. Cell Death Differ. 2023 Jan;30 (1) :168-183.|[3]Kumawat S, et al. Dearomative Difluoromethylation of N-Heterocycles and Pharmaceuticals with Bromo (difluoro) acetic Acid. J Org Chem. 2025 Jul 18;90 (28) :9826-9844.