Ethylenediaminetetraacetic acid-d12

Ethylenediaminetetraacetic acid-d12 is the deuterium labeled Ethylenediaminetetraacetic acid[1]. Ethylenediaminetetraacetic acid (EDTA) is a metal chelators (binds to metal divalent and trivalent cations including calcium), which shows activities of anticoagulant and anti-hypercalcemic. Ethylenediaminetetraacetic acid decreases the metal ion-catalyzed oxidative damage to proteins, and allows maintenance of reducing environment during protein purification. Ethylenediaminetetraacetic acid can also decrease the formation of disulfide bonds[2][3][4].

Product Specifications

CAS Number

[203806-08-0]

Product Name Alternative

EDTA-d12

UNSPSC

12352211

Hazard Statement

H319

Target

Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Others

Field of Research

Neurological Disease

Purity

98.00

Solubility

0.1 M NaOH : 6.67 mg/mL (ultrasonic; warming; adjust pH to 7 with NaOH)

Smiles

OC(C([2H])([2H])N(C([2H])([2H])C(O)=O)C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C(O)=O)C([2H])([2H])C(O)=O)=O

Molecular Formula

C10H4D12N2O8

Molecular Weight

304.32

Precautions

H319

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Chumanov RS, et al. Artifact-inducing enrichment of ethylenediaminetetraacetic acid and ethyleneglycoltetraacetic acid on anion exchange resins. Anal Biochem. 2011 May 1;412 (1) :34-9. |[3]Banfi G, et al. The role of ethylenediamine tetraacetic acid (EDTA) as in vitro anticoagulant for diagnostic purposes. Clin Chem Lab Med. 200745 (5) :565-76. |[4]Ibad A, et al. Chelation therapy in the treatment of cardiovascular diseases. J Clin Lipidol. 2016 Jan-Feb10 (1) :58-62.