Kaempferol-7,4'-dimethyl ether

Kaempferol-7,4'-dimethyl ether is a PTP1B inhibitor, and also can inhibit the production of NO. Kaempferol-7,4'-dimethyl ether shows the inhibition rate of 46.1% at 100 μM. Kaempferol-7,4'-dimethyl ether inhibits PTP1B activity with IC50 value of 16.92 μM[1][2].

Product Specifications

CAS Number

[15486-33-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Others; Phosphatase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/kaempferol-7-4-dimethyl-ether.html

Purity

98.23

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 0.5 mg/mL (ultrasonic)

Smiles

O=C1C(O)=C(C2=CC=C(OC)C=C2)OC3=CC(OC)=CC(O)=C13

Molecular Formula

C17H14O6

Molecular Weight

314.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Teeratad, et al. Inhibition of nitric oxide production by compounds from Boesenbergia longiflora using lipopolysaccharide-stimulated RAW264.7 macrophage cells.[J]. Songklanakarin Journal of Science & Technology, 2013.|[2]To D-C, et al. PTP1B Inhibitory Flavonoids From Orthosiphon stamineus Benth. and Their Growth Inhibition on Human Breast Cancer Cells. Natural Product Communications. 2020,15 (1) .