(±) -Shikonin
Product Specifications
CAS Number
54952-43-1
Synonyms
C.I. 75535, Anchusin, Anchusa acid, Alkanna Red, Isoarnebin 4, NSC 252844
Target
Chloride Channel
Applications
Transmembrane Transporters
Molecular Formula
C16H16O5
Additionnal Information
(±) -Shikonin, a potent and specific Pyruvate kinase M2 (PKM2) inhibitor, is a major component of zicao (purple gromwell, the dried root of Lithospermum erythrorhizon), a Chinese herbal medicine with various biological activities. It is also an inhibitor of TMEM16A chloride channel activity using cell-based fluorescent-quenching assay. Shikonin exerts an anti-inflammatory effect by inhibiting tumor necrosis factor-α (TNF-α) and prevents activation of nuclear factor-κB (NF-κB) pathway via proteasome inhibition.
Storage Conditions
2 years -80 in solvent
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