AMG 232 (KRT-232)
Product Specifications
CAS Number
1352066-68-2
Synonyms
Navtemadlin
Target
MDM2/MDMX
Applications
Apoptosis
Molecular Formula
C28H35Cl2NO5S
Additionnal Information
AMG 232 (Navtemadlin) is a potential, selective inhibitor of the MDM2–p53 interaction, with an IC50 of 0.6 nM and binds to MDM2 with a Kd of 0.045 nM. It also demonstrated antitumor activity in vivo in a variety of tumor types with different genetic backgrounds.
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