GSK2606414
Product Specifications
CAS Number
1337531-36-8
Target
PERK
Applications
Apoptosis
Smiles
CN1C=C (C2=C (N=CN=C21) N) C3=CC4=C (C=C3) N (CC4) C (=O) CC5=CC (=CC=C5) C (F) (F) F
Molecular Formula
C24H20F3N5O
Additionnal Information
GSK2606414 is an orally available, potent, and selective PERK inhibitor with IC50 of 0.4 nM, displaying at least 100-fold selectivity over the other EIF2AKs assayed. GSK2606414 impairs GANT-61 induced autophagy in NB cells with MYCN amplification. GSK2606414 exacerbates ER stress-induced apoptosis in HCT116 cells while reduces the apoptosis in SIL1 KD HeLa cells.
Storage Conditions
2 years -80 in solvent
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
K2416502 1.0 µg DNA
TNFRSF17 sgRNA CRISPR Lentivector (Human) (Target 1)
Sign In for Pricing
View Details NBP3-26039PE 0.1 mL
Rabbit Monoclonal 25-OH Vitamin D3 Antibody-antigen Complex Antibody (RM428) [PE]
Sign In for Pricing
View Details 
TRV-0027257 96 Tests
Multiplex Assay Kit for Angiopoietin-3 (ANG-3), etc. by FLIA (Flow Luminescence Immunoassay)
Sign In for Pricing
View Details orb2921868-01 20 µg
Recombinant Bactoprenol-linked glucose translocase (rfbI)
Sign In for Pricing
View Details orb2921868-02 100 µg
Recombinant Bactoprenol-linked glucose translocase (rfbI)
Sign In for Pricing
View Details