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Molibresib (I-BET-762)

Product Specifications

CAS Number

1260907-17-2

Synonyms

GSK525762, GSK525762A

Target

Epigenetic Reader Domain

Applications

Epigenetics

Smiles

CCNC (=O) CC1C2=NN=C (N2C3=C (C=C (C=C3) OC) C (=N1) C4=CC=C (C=C4) Cl) C

Molecular Formula

C22H22ClN5O2

Additionnal Information

Molibresib (I-BET-762, GSK525762, GSK525762A) is an inhibitor for BET proteins with IC50 of ~35 nM in a cell-free assay, suppresses the production of proinflammatory proteins by macrophages and blocks acute inflammation, highly selective over other bromodomain-containing proteins.

Storage Conditions

2 years -80 in solvent

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