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Ataluren (PTC124)

Product Specifications

CAS Number

775304-57-9

Target

CFTR

Applications

Transmembrane Transporters

Smiles

C1=CC=C (C (=C1) C2=NC (=NO2) C3=CC (=CC=C3) C (=O) O) F

Molecular Formula

C15H9FN2O3

Additionnal Information

Ataluren (PTC124) selectively induces ribosomal read-through of premature but not normal termination codons, with EC50 of 0.1 μM in HEK293 cells, may provide treatment for genetic disorders caused by nonsense mutations (e.g. CF caused by CFTR nonsense mutation) . Phase 3.

Storage Conditions

2 years -80 in solvent

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