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PHA-767491 HCl

Product Specifications

CAS Number

942425-68-5

Synonyms

CAY10572, NMS 1116354

Target

CDK

Applications

Cell Cycle

Smiles

C1CNC (=O) C2=C1NC (=C2) C3=CC=NC=C3.Cl

Molecular Formula

C12H11N3O.HCl

Additionnal Information

PHA-767491 (CAY10572, NMS 1116354) HCl is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM in cell-free assays, respectively.It displays ~20-fold selectivity against CDK1/2 and GSK3-β, 50-fold selectivity against MK2 and CDK5, 100-fold selectivity against PLK1 and CHK2.

Storage Conditions

2 years -80 in solvent

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