Amuvatinib (MP-470)
Product Specifications
CAS Number
850879-09-3
Synonyms
HPK 56
Target
C-Kit
Applications
Protein Tyrosine Kinase
Smiles
C1CN (CCN1C2=NC=NC3=C2OC4=CC=CC=C43) C (=S) NCC5=CC6=C (C=C5) OCO6
Molecular Formula
C23H21N5O3S
Additionnal Information
Amuvatinib (MP-470, HPK 56) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. Amuvatinib suppresses c-MET and c-RET. Amuvatinib is also active as a DNA repair protein Rad51 inhibitor with antineoplastic activity. Phase 2.
Storage Conditions
2 years -80 in solvent
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