Apilimod mesylate
Product Specifications
CAS Number
870087-36-8
Synonyms
STA-5326 mesylate
Target
Interleukins
Applications
Immunology & Inflammation
Smiles
CC1=CC (=CC=C1) C=NNC2=CC (=NC (=N2) OCCC3=CC=CC=N3) N4CCOCC4.CS (=O) (=O) O.CS (=O) (=O) O
Molecular Formula
C25H34N6O8S2
Additionnal Information
Apilimod mesylate is a potent and orally-available inhibitor of the cytokines interleukin-12 (IL-12) and interleukin-23 (IL-23) with the potential to treat certain autoimmune and inflammatory diseases. Apilimod mesylate (STA-5326 mesylate) inhibits IL-12 with IC50 of 1 nM, 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs, human monocytes and mouse PBMCs, respectively. Apilimod mesylate (STA-5326 mesylate) is also a cell permeable small molecule that specifically inhibits PIKfyve with IC50 of 14 nM.
Storage Conditions
3 years -20°C powder
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS1480273 Inquire
Recombinant Staphylococcus saprophyticus subsp. saprophyticus DNA mismatch repair protein mutL (mutL), partial
Sign In for Pricing
View Details 
MBS6401291-01 0.1 mL
MTHFD2 (NMDMC, Bifunctional Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase, Mitochondrial, NAD-dependent Methylenetetrahydrofolate Dehydrogenase, Methenyltetrahydrofolate Cyclohydrolase) (MaxLight 490)
Sign In for Pricing
View Details 
MBS6401291-02 5x 0.1 mL
MTHFD2 (NMDMC, Bifunctional Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase, Mitochondrial, NAD-dependent Methylenetetrahydrofolate Dehydrogenase, Methenyltetrahydrofolate Cyclohydrolase) (MaxLight 490)
Sign In for Pricing
View Details