Oxyclozanide

Oxyclozanide is an orally active salicylanilide anthelmintic agent that mainly acts by uncoupling oxidative phosphorylation in flukes. Oxyclozanide shows good anti-adenovirus, anti-biofilm, antifungal, and antibacterial activity[1][2][3].

Product Specifications

CAS Number

[2277-92-1]

UNSPSC

12352005

Hazard Statement

H302, H410

Target

Bacterial; Fungal; Oxidative Phosphorylation; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Oxyclozanide.html

Purity

98.85

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC(Cl)=CC(Cl)=C1O)C2=C(O)C(Cl)=CC(Cl)=C2Cl

Molecular Formula

C13H6Cl5NO3

Molecular Weight

401.46

Precautions

H302, H410

References & Citations

[1]Georgiev B, Gruev A. Efektivnost na levamizole i oxyclozanide sreshtu paramfistomatozata po ovtsete i govedata [Effectiveness of levamisole and oxyclozanide in paramphistomiasis in sheep and cattle]. Vet Med Nauki. 1979;16 (3) :45-51.|[2]Wang W, et al. Acute and Subacute Toxicity Assessment of Oxyclozanide in Wistar Rats. Front Vet Sci. 2019 Sep 6;6:294.|[3]Levinson MR, et al. The in vitro antibacterial activity of the anthelmintic drug oxyclozanide against common small animal bacterial pathogens. Vet Dermatol. 2019 Aug;30 (4) :314-e87.