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Macitentan-d4

Macitentan-d4 is a deuterium labeled Sulfamethoxazole. Macitentan is an orally active, non-peptide dual ETA and ETB (endothelin) receptor antagonist. Macitentan has the potential for idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH) [1].

Product Specifications

CAS Number

1258428-05-5

Product Name Alternative

ACT-064992-d4

UNSPSC

12352005

Target

Apoptosis; Endothelin Receptor; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; GPCR/G Protein; Others

Applications

Neuroscience-Neurodegeneration

Field of Research

Cardiovascular Disease

Purity

98.03

Solubility

DMSO : ≥ 50mg/mL

Smiles

O=S(NCCC)(NC1=NC=NC(OC([2H])([2H])C([2H])([2H])OC2=NC=C(Br)C=N2)=C1C3=CC=C(Br)C=C3)=O

Molecular Formula

C19H16D4Br2N6O4S

Molecular Weight

592.30

References & Citations

[1]Corallo C, et al. Bosentan and macitentan prevent the endothelial-to-mesenchymal transition (EndoMT) in systemic sclerosis: in vitro study. Arthritis Res Ther. 2016 Oct 6;18 (1) :228.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Isoform

ETA; ETB

Available Sizes

Frequently Asked Questions

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