What is the catalog number for RMC-4998?

The catalog number for RMC-4998 is C01979-100mg.

What sizes are available for RMC-4998?

RMC-4998 is available in the following size(s): 100 mg.

Is RMC-4998 in stock?

RMC-4998 is currently made to order / not held in immediate stock. Contact us for lead time.

RMC-4998

Product Specifications

CAS Number

2642037-07-6

Target

Ras

Applications

Apoptosis

Molecular Formula

C57H74N8O7

Additionnal Information

RMC-4998 is a tri-complex inhibitor that selectively targets the GTP-bound state of mutant KRASG12C, with high potency for KRASG12C-CYPA tri-complex formation with an IC50 of 28 nM. It strongly inhibits ERK signaling with an IC50 of 1–10 nM and attenuates AKT/MTOR and RAL pathways, leading to potent suppression of KRASG12C-driven tumor growth and can used in cancer research.