CDC801

CDC801 is a potent and orally active phosphodiesterase 4 (PDE4) and tumor necrosis factor-α (TNF-α) inhibitor with IC50 of 1.1 μM and 2.5 μM, respectively.

Product Specifications

CAS Number

[192819-27-5]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Phosphodiesterase (PDE) ; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CDC801.html

Concentration

10mM

Purity

98.94

Solubility

10 mM in DMSO

Smiles

NC(CC(C1=CC(OC2CCCC2)=C(OC)C=C1)N3C(C4=C(C=CC=C4)C3=O)=O)=O

Molecular Formula

C23H24N2O5

Molecular Weight

408.45

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Man HW, et al. Discovery of (S) -N-[2-[1- (3-ethoxy-4-methoxyphenyl) -2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl] acetamide (apremilast), a potent and orally active phosphodiesterase 4and tumor necrosis factor-alpha inhibitor. J Med Chem. 2009 Mar 26;52 (6) :1522-4.