BBI-2779

Product Specifications

CAS Number

2871057-47-3

Target

Chk

Applications

Cell Cycle

Smiles

COC1=CC=CC (O[C@H]2[C@@H] (CC2) N) =C1C3=CC (NC4=NC=C (C#N) N=C4) =NN3

Molecular Formula

C19H19N7O2

Additionnal Information

BBI-2779 is a potent, selective, and orally active inhibitor of CHK1 with an IC50 of 0.3 nM. It preferentially kills cancer cells containing extrachromosomal DNA (ecDNA) by inducing replication stress and cell death. In gastric cancer models with FGFR2 gene amplification on ecDNA, BBI-2779 suppresses tumor growth and prevents drug resistance.