Anti-Hu CD183 Purified
CD184 is a 7-transmembrane G-protein coupled receptor for the C-X-C chemokines SDF-1 (CXCL12), MIG (CXCL9) and IP10 (CXCL10) . Alternatively spliced variant CD184B serves as the high affinity receptor for PF4 (CXCL4) . CD184 is expressed in hematopoietic cells, vascular endothelium, and neural tissue. It plays important roles in endothelial vascularization and central nervous system development. It can also serve as a primary receptor or a coreceptor for some HIV isolates. CD184 signaling leads to integrin activation, cytoskeletal changes and chemotactic migration.
Product Specifications
Certification
RUO
Target Antigen
CD183
Clone
RHIQB005
Applications
FC (QC tested)
Concentration
1 mg/mL
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The recombinant mouse monoclonal antibody rHIQB005 recognizes an extracellular epitope on human chemokine receptor CD184.
Applications Notes
Flow cytometry: Recommended dilution: 1-5 μg/ml
Species
Human
Isotype
Mouse IgG1
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