Anti-Hu CD183 Purified
CD184 is a 7-transmembrane G-protein coupled receptor for the C-X-C chemokines SDF-1 (CXCL12), MIG (CXCL9) and IP10 (CXCL10) . Alternatively spliced variant CD184B serves as the high affinity receptor for PF4 (CXCL4) . CD184 is expressed in hematopoietic cells, vascular endothelium, and neural tissue. It plays important roles in endothelial vascularization and central nervous system development. It can also serve as a primary receptor or a coreceptor for some HIV isolates. CD184 signaling leads to integrin activation, cytoskeletal changes and chemotactic migration.
Product Specifications
Certification
RUO
Reactivity
Human
Target Antigen
CD183
Clone
RHIQB005
Applications
FC (QC tested)
Concentration
1 mg/mL
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The recombinant mouse monoclonal antibody rHIQB005 recognizes an extracellular epitope on human chemokine receptor CD184.
Applications Notes
Flow cytometry: Recommended dilution: 1-5 μg/ml
Isotype
Mouse IgG1
Frequently Asked Questions
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