Sunitinib malate
Product Specifications
CAS Number
341031-54-7
Synonyms
SU11248 malate
Target
C-Kit
Applications
Protein Tyrosine Kinase
Smiles
CCN (CC) CCNC (=O) C1=C (NC (=C1C) C=C2C3=C (C=CC (=C3) F) NC2=O) C.C (C (C (=O) O) O) C (=O) O
Molecular Formula
C22H27FN4O2.C4H6O5
Additionnal Information
Sunitinib malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM in cell-free assays, and also inhibits c-Kit. Sunitinib Malate effectively inhibits autophosphorylation of Ire1α. Sunitinib Malate increases both death receptor and mitochondrial-dependent apoptosis.
Storage Conditions
2 years -80 in solvent
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