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Padnarsertib (KPT 9274)

Product Specifications

CAS Number

1643913-93-2

Target

NAMPT

Applications

Metabolism

Smiles

C1CN (CCC1 (F) F) C (=O) C2=CC=C (C=C2) C3=CC (=C4C (=C3) C=C (O4) CNC (=O) C=CC5=CN=C (C=C5) N) C6=CC=C (C=C6) F

Molecular Formula

C35H29F3N4O3

Additionnal Information

Padnarsertib (KPT 9274) is an orally bioavailable small molecule that is a non-competitive dual inhibitor of PAK4 and NAMPT. It shows an IC50 of ~120 nM for NAMPT in a cell-free enzymatic assay.

Storage Conditions

2 years -80 in solvent

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