FK506
FKBP inhibitor
Product Specifications
Background
FK506 or Fujimycin or Tacrolimus, is an immunosuppressant. It is mainly used after allogeneic organ transplants, but can also be used topically in the treatment of eczema, uveitis and vitiligo (1). It is a macrolide that prevents the dephosphorylation of NF-AT. It reduces peptidyl-prolyl isomerase activity by binding to FKBP12 creating a new complex that interacts with and inhibits calcineurin (2, 3). It is a neuroprotective in a model of antiretroviral toxic neuropathy (4).
CAS Number
104987-11-3
Product Name Alternative
3- (3-Pyridinyl) propyl 1- (3,3-dimethyl-2-oxopentanoyl) prolinate, Tacrolimus, Fujimycin
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis | Neuroscience | Cell Death | Necroptosis
Purity
>98%
Weight
0.05
Format
White powder
Solubility
May be dissolved in DMSO (50 mg/mL) or ethanol (50mg/mL)
Molecular Formula
C44H69HO12
Molecular Weight
804
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Nanette B., et al. (2004) J Am Acad Derm. 51(5): 760-766.
2. Ganong W.F., Review of Medical Physiology (22nd ed.) Lange Medical Books. P.530
3. Liu J. Lane W., Friedman J, Weissman I and Schreiber S. (1991) Cell. 66(4): 807-815 4. Keswani S., et al. (2003) Ann Neurol. 53(1): 57-64.
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
