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CPI-455 HCl

Product Specifications

CAS Number

2095432-28-1

Target

Histone Demethylase

Applications

Epigenetics

Smiles

CC (C) C1=C (N=C2C (=CNN2C1=O) C#N) C3=CC=CC=C3.Cl

Molecular Formula

C16H15ClN4O

Additionnal Information

CPI-455 HCl is a specific KDM5 inhibitor with a half-maximal inhibitory concentration (IC50) of 10 ± 1 nM for full-length KDM5A in enzymatic assays, elevating global levels of H3K4 trimethylation (H3K4me3) and decreased the number of DTPs in multiple cancer cell line models treated with standard chemotherapy or targeted agents.

Storage Conditions

2 years -80 in solvent

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