Infigratinib (BGJ398)
Product Specifications
CAS Number
872511-34-7
Synonyms
NVP-BGJ398
Target
FGFR
Applications
Protein Tyrosine Kinase
Smiles
CCN1CCN (CC1) C2=CC=C (C=C2) NC3=CC (=NC=N3) N (C) C (=O) NC4=C (C (=CC (=C4Cl) OC) OC) Cl
Molecular Formula
C26H31Cl2N7O3
Additionnal Information
Infigratinib (BGJ398) is a potent and selective FGFR inhibitor for FGFR1/2/3 with IC50 of 0.9 nM/1.4 nM/1 nM in cell-free assays, >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes. Phase 2.
Storage Conditions
2 years -80 in solvent
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