L-2-Hydroxyglutaric acid disodium
Product Specifications
CAS Number
63512-50-5
Synonyms
(S) -2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG
Target
Histone Demethylase
Applications
Epigenetics
Smiles
[Na+].[Na+].OC (CCC ([O-]) =O) C ([O-]) =O
Molecular Formula
C5H6Na2O5
Additionnal Information
L-2-Hydroxyglutaric acid disodium ((S) -2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation. L-2-Hydroxyglutaric acid disodium is also an inhibitor of mitochondrial creatine kinase (Mi-CK) with Km and Ki of 2.52 mM and 11.13 mM, respectively.
Storage Conditions
3 years -20°C powder
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